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Saccharin may lead to weight gain http://apocadocs.com/s.pl?1202763960 
"Casting doubt on the benefit of low-calorie sweeteners, research released Sunday reported that rats on diets containing saccharin gained more weight than rats given sugary food. The study in the journal Behavioral Neuroscience found that the calorie-free artificial sweetener appeared to break the physiological connection between sweet tastes and calories, driving the rats to overeat. Lyn M. Steffen, an associate professor of epidemiology at the University of Minnesota, who was not involved in the latest report, said the study offered a possible explanation for the unexpected association between obesity and diet soda found in recent human studies." 
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This story is so ironic, it's post-ironic. The fat rats aren't laughing, though.
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